Sickle cell and thalassaemia screening programme lab support service


The purpose of the service is to provide technical and scientific support to UK Sickle Cell and Thalassaemia screening laboratories via help lines and teaching/training days. The service was commissioned by the National Sickle Cell and Thalassaemia Screening Programme.

Who can access the service

The service has been set up primarily to support staff in haemoglobinopathy screening laboratories, but we are very happy to answer queries from any other health professional requiring advice interpreting haemoglobinopathy laboratory results.

Things the service help with

We can help with all aspects of the laboratory diagnosis of haemoglobinopathies but areas we are often asked about include:

  • Interpretation of HPLC, FBC, results and electrophoresis results
  • Interpretation of borderline results
  • Information concerning alpha thalassaemia phenotypes/genotypes
  • Information concerning HPFH/delta-beta thalassaemia phenotypes
  • When partner testing should be recommended
  • How results should be reported when the results are not clear cut
  • When samples should be referred for further testing (e.g., mass spec or genetic testing)
  • When results should be referred to clinical staff
  • The clinical significance of rare haemoglobin variants

More details about the service and how it can be accessed can be obtained from the Sickle Cell and Thalassaemia screening programme website at www.sct.screening.nhs.uk/.

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Last updated 23 Feb 2017.