Molecular Haemato-Oncology

We carry out an extensive range of molecular investigations which can assist with the diagnosis, prognosis, therapy and monitoring of haematological malignancies. We also offer a Specialist Integrated Haematological Malignancy Diagnostic Service (SIHMDS). The operation policy for this can be found here.

Disorder Test         
Chronic Myeloid Leukaemia BCR-ABL by multiplex PCR and quantitative real time PCR
BCR-ABL tyrosine kinase domain mutations
Acute Myeloid Leukaemia NPM1
FLT3 ITD and D835 TK
Acute Lymphocytic Leukaemia (Philadelphia Chromosome Positive) BCR-ABL by multiplex PCR and quantitative real time PCR
Lymphoma : B cell clonality IgH FR1, FR2, FR3 re-arrangements
IgH incomplete D-J re-arrangements using BIOMED 2 CE marked primers
Lymphoma: T cell clonality TCRB and TCRG and TCRD gene rearrangements using BIOMED 2 CE marked primers
Chronic Lymphocytic Leukaemia Integrated TP53 mutation analysis using NGS and FISH 
Myeloproliferative neoplasms JAK2 V617F mutation by allele specific PCR and pyrosequencing
Haemopoietic Stem Cell Transplantation Chimerism by STR analysis (total white cell, CD3 and CD34 positive cells)
Myeloid Disorders NGS gene panel


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Last updated 21 May 2018